Resultados da pesquisa - Abhishek A. Chakraborty

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  1. 1
    On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

    On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models Por Hyejin Cho, Xinlin Du, James P. Rizzi, Ella Liberzon, Abhishek A. Chakraborty, Wenhua Gao, Ingrid Carvo, Sabina Signoretti, Richard K. Bruick, John A. Josey, Eli M. Wallace, William G. Kaelin

    Publicado em 2016
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  2. 2
    pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner

    pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner Por Jianping Guo, Abhishek A. Chakraborty, Pengda Liu, Wenjian Gan, Xingnan Zheng, Hiroyuki Inuzuka, Bin Wang, Jinfang Zhang, Linli Zhang, Min Yuan, Jesse Novak, Jin Q. Cheng, Alex Toker, Sabina Signoretti, Qing Zhang, John M. Asara, William G. Kaelin, Wenyi Wei

    Publicado em 2016
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  3. 3
    H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancer

    H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancer Por Mehdi Baratchian, Ritika Tiwari, Sirvan Khalighi, Ankur Chakravarthy, Wei Yuan, Michael Berk, Jianneng Li, Amy Guerinot, Johann S. de Bono, Vladimir Makarov, Timothy A. Chan, Robert H. Silverman, George R. Stark, Vinay Varadan, Daniel D. De Carvalho, Abhishek A. Chakraborty, Nima Sharifi

    Publicado em 2022
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  4. 4
    VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms

    VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms Por Keman Zhang, Amin Zakeri, Tyler J. Alban, Juan Dong, Hieu Minh Ta, Ajay Zalavadia, Andrelie Branicky, Haoxin Zhao, Ivan Jurić, Hana Husic, Prerana Bangalore Parthasarathy, Amit Rupani, Judy Drazba, Abhishek A. Chakraborty, Stanley Ching‐Cheng Huang, Timothy A. Chan, Stefanie Avril, Li Lily Wang

    Publicado em 2024
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  5. 5
    EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

    EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection Por Benjamin A. Olenchock, Javid J. Moslehi, Alan H. Baik, Shawn M. Davidson, Jeremy Williams, William J. Gibson, Abhishek A. Chakraborty, Kerry A. Pierce, Christine Miller, Eric A. Hanse, Ameeta Kelekar, Lucas B. Sullivan, Amy J. Wagers, Clary B. Clish, Matthew G. Vander Heiden, William G. Kaelin

    Publicado em 2016
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  6. 6
    HIF activation causes synthetic lethality between the <i>VHL</i> tumor suppressor and the <i>EZH1</i> histone methyltransferase

    HIF activation causes synthetic lethality between the <i>VHL</i> tumor suppressor and the <i>EZH1</i> histone methyltransferase Por Abhishek A. Chakraborty, Eijiro Nakamura, Jun Qi, Amanda L. Creech, Jacob D. Jaffe, Joshiawa Paulk, Jesse Novak, Kshithija Nagulapalli, Samuel K. McBrayer, Glenn S. Cowley, Javier Pineda, Jiaxi Song, Yaoyu E. Wang, Steven A. Carr, David E. Root, Sabina Signoretti, James E. Bradner, William G. Kaelin

    Publicado em 2017
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  7. 7
    Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

    Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate Por Abhishek A. Chakraborty, Tuomas Laukka, Matti Myllykoski, Alison E. Ringel, Matthew A. Booker, Michael Tolstorukov, Yuzhong Jeff Meng, Samuel R. Meier, Rebecca B. Jennings, Amanda L. Creech, Zachary T. Herbert, Samuel K. McBrayer, Benjamin A. Olenchock, Jacob D. Jaffe, Marcia C. Haigis, Rameen Beroukhim, Sabina Signoretti, Peppi Koivunen, William G. Kaelin

    Publicado em 2019
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  8. 8
    The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis

    The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis Por Matthew G. Oser, Amin H. Sabet, Wenhua Gao, Abhishek A. Chakraborty, Anna C. Schinzel, Rebecca B. Jennings, Raquel Fonseca, Dennis M. Bonal, Matthew A. Booker, Abdallah Flaifel, Jesse Novak, Camilla L. Christensen, Hua Zhang, Zachary T. Herbert, Michael Tolstorukov, Elizabeth Buss, Kwok‐Kin Wong, Roderick T. Bronson, Quang‐Dé Nguyen, Sabina Signoretti, William G. Kaelin

    Publicado em 2019
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  9. 9
    Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

    Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase Por Xingnan Zheng, Bo Zhai, Peppi Koivunen, Sandra J. Shin, Gang Lü, Jiayun Liu, Christoph Geisen, Abhishek A. Chakraborty, Javid J. Moslehi, David M. Smalley, Xin Wei, Xian Chen, Zhengming Chen, Justine M. Beres, Jing Zhang, Jen-Lan Tsao, Mitchell C. Brenner, Yuqing Zhang, Cheng Fan, Ronald A. DePinho, Jihye Paik, Steven P. Gygi, William G. Kaelin, Qing Zhang

    Publicado em 2014
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  10. 10
    Cells Lacking the <i>RB1</i> Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

    Cells Lacking the <i>RB1</i> Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival Por Matthew G. Oser, Raquel Fonseca, Abhishek A. Chakraborty, Rachel Brough, Alexander Spektor, Rebecca B. Jennings, Abdallah Flaifel, Jesse Novak, Aditi Gulati, Elizabeth Buss, Scott T. Younger, Samuel K. McBrayer, Glenn S. Cowley, Dennis M. Bonal, Quang-Dé Nguyen, Laura Brullé-Soumaré, Paula Taylor, Stefano Cairo, Colm J. Ryan, Elizabeth J. Pease, Kim Maratea, Jon Travers, David E. Root, Sabina Signoretti, David Pellman, Susan Ashton, Christopher J. Lord, Simon T. Barry, William G. Kaelin

    Publicado em 2018
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  11. 11
    Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

    Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma Por Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan Looper, Keith L. Ligon, B Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin

    Publicado em 2018
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  12. 12
    GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity

    GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity Por Dionysios C. Watson, Defne Bayık, Simon Storevik, Shannon Sherwin Moreino, Samuel A. Sprowls, Jianhua Han, Mina Thue Augustsson, Adam Lauko, Sravya Palavalasa, Gro Vatne Røsland, Katie Troike, Karl Johan Tronstad, Sabrina Wang, Katharina Sarnow, Kristen Kay, Taral R. Lunavat, Daniel J. Silver, Sahil Dayal, Justin V. Joseph, Erin E. Mulkearns-Hubert, Lars Ystaas, Gauravi Deshpande, Joris Guyon, Yadi Zhou, Capucine Magaut, Juliana Seder, Laura Neises, Sarah Williford, Johannes Meiser, Andrew J. Scott, Peter Sajjakulnukit, Jason A. Mears, Rolf Bjerkvig, Abhishek A. Chakraborty, Thomas Daubon, Feixiong Cheng, Costas A. Lyssiotis, Daniel Wahl, Anita B. Hjelmeland, Jubayer A. Hossain, Hrvoje Miletić, Justin D. Lathia

    Publicado em 2023
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