Rezultaty - Guillaume Lessène

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  1. 1
    Inhibitors of SARS-CoV-2 PLpro

    Inhibitors of SARS-CoV-2 PLpro od Dale J. Calleja, Guillaume Lessène, David Komander

    Wydane 2022
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  2. 2
    Cell death and the mitochondria: therapeutic targeting of the <scp>BCL</scp>‐2 family‐driven pathway

    Cell death and the mitochondria: therapeutic targeting of the <scp>BCL</scp>‐2 family‐driven pathway od Michael J. Roy, Amelia Vom, Peter E. Czabotar, Guillaume Lessène

    Wydane 2013
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  3. 3
    BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

    BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines od Delphine Mérino, Gemma L. Kelly, Guillaume Lessène, Andrew H. Wei, Andrew W. Roberts, Andreas Strasser

    Wydane 2018
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  4. 4
    Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

    Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use od Margs S. Brennan, Catherine Chang, Lin Tai, Guillaume Lessène, Andreas Strasser, Grant Dewson, Gemma L. Kelly, Marco J. Herold

    Wydane 2018
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  5. 5
    From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors

    From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors od Christopher R. Gardner, Katherine A. Davies, Ying Zhang, Martin Brzozowski, Peter E. Czabotar, James M. Murphy, Guillaume Lessène

    Wydane 2023
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  6. 6
    Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

    Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands od Erinna F. Lee, Peter E. Czabotar, Hong Yang, Brad E. Sleebs, Guillaume Lessène, Peter M. Colman, Brian J. Smith, W. Douglas Fairlie

    Wydane 2009
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  7. 7
    Analysis of Ca <sup>2</sup> <sup>+</sup> mediated signaling regulating <i>Toxoplasma</i> infectivity reveals complex relationships between key molecules

    Analysis of Ca <sup>2</sup> <sup>+</sup> mediated signaling regulating <i>Toxoplasma</i> infectivity reveals complex relationships between key molecules od Rebecca J. Stewart, Lachlan Whitehead, Brunda Nijagal, Brad E. Sleebs, Guillaume Lessène, Malcolm J. McConville, Kelly L. Rogers, Christopher J. Tonkin

    Wydane 2016
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  8. 8
    Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

    Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1 od Jia-Nan Gong, Tiffany Khong, David Segal, Yuan Yao, Chris Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessène, Andrew Spencer, Marco J. Herold, Andrew W. Roberts, David C.S. Huang

    Wydane 2016
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  9. 9
    Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

    Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production od M. J. D. White, Kate McArthur, Donald Metcalf, Rachael M. Lane, John C. Cambier, Marco J. Herold, Mark F. van Delft, Sammy Bedoui, Guillaume Lessène, Matthew E. Ritchie, David C.S. Huang, Benjamin T. Kile

    Wydane 2014
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  10. 10
    Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

    Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations od Richard W. Birkinshaw, Jianan Gong, Cindy S. Luo, Daisy Lio, Christine White, Mary Ann Anderson, Piers Blombery, Guillaume Lessène, Ian J. Majewski, Rachel Thijssen, Andrew W. Roberts, David C.S. Huang, Peter M. Colman, Peter E. Czabotar

    Wydane 2019
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  11. 11
    BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells

    BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells od Diane Moujalled, Adam Southon, Eiman Saleh, Kerstin Brinkmann, Francine Ke, Melinda Iliopoulos, Ryan S. Cross, Misty R. Jenkins, Duong Nhu, Zilu Wang, Melissa X. Shi, Ruth M. Kluck, Guillaume Lessène, Stephanie Grabow, Ashley I. Bush, Andreas Strasser

    Wydane 2022
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  12. 12
    Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

    Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression od Ashleigh R. Poh, Christopher G. Love, Frédérick Masson, Adele Preaudet, Cary Tsui, Lachlan Whitehead, Simon Monard, Yelena Khakham, Lotta Burstroem, Guillaume Lessène, Oliver M. Sieber, Clifford Lowell, Tracy L. Putoczki, Robert J.J. O’Donoghue, Matthias Ernst

    Wydane 2017
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  13. 13
    HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

    HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death od Annette V. Jacobsen, Kym N. Lowes, Maria C. Tanzer, Isabelle S. Lucet, Joanne M. Hildebrand, Emma J. Petrie, Mark F. van Delft, Zikou Liu, Stephanie A. Conos, Jian‐Guo Zhang, David C.S. Huang, John Silke, Guillaume Lessène, James M. Murphy

    Wydane 2016
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  14. 14
    Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

    Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis od Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy S. Luo, Jean‐Marc Garnier, Lung‐Yu Liang, Angus D. Cowan, André L. Samson, Guillaume Lessène, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy

    Wydane 2021
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  15. 15
    ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types

    ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types od Anderly C. Chüeh, Janson W.T. Tse, Michael Dickinson, Paul Ioannidis, Laura J. Jenkins, Lars Tögel, BeeShin Tan, Ian Y. Luk, Mercedes Dávalos-Salas, Rebecca Nightingale, Matthew R. Thompson, Bryan Williams, Guillaume Lessène, Erinna F. Lee, W. Douglas Fairlie, Amardeep S. Dhillon, John M. Mariadason

    Wydane 2017
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  16. 16
    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer od S. A. Berger, Erik Procko, Daciana Margineantu, Erinna F. Lee, Betty Shen, Alex Zelter, Daniel‐Adriano Silva, Kusum Chawla, Marco J. Herold, Jean-Marc Garnier, Richard S. Johnson, Michael J. MacCoss, Guillaume Lessène, Trisha N. Davis, Patrick S. Stayton, Barry Stoddard, W. Douglas Fairlie, David M. Hockenbery, David Baker

    Wydane 2016
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  17. 17
    The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

    The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells od Zilu Wang, Huimin Hu, Luuk Heitink, Kelly L. Rogers, Yue You, Tao Tan, Connie S.N. Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T. Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate D. Sutherland, Guillaume Lessène, Oliver M. Sieber, Jane E. Visvader, Gemma L. Kelly, Andreas Strasser

    Wydane 2023
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  18. 18
    The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

    The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation od James E. Vince, Dominic De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine Hall, Kate McArthur, Daniel S. Simpson, Swarna Lekha Vijayaraj, Lisa Lindqvist, Philippe Bouillet, Mark A. Rizzacasa, Si Ming Man, John Silke, Seth L. Masters, Guillaume Lessène, David C.S. Huang, Daniel H.D. Gray, Benjamin T. Kile, Feng Shao, Kate E. Lawlor

    Wydane 2018
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  19. 19
    Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

    Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3 od Emma J. Petrie, Jarrod J. Sandow, Wil I. L. Lehmann, Lung‐Yu Liang, Diane Coursier, Samuel N. Young, Wilhelmus J. A. Kersten, Cheree Fitzgibbon, André L. Samson, Annette V. Jacobsen, Kym N. Lowes, Amanda E. Au, Hélène Jousset Sabroux, Najoua Lalaoui, Andrew I. Webb, Guillaume Lessène, Gerard Manning, Isabelle S. Lucet, James M. Murphy

    Wydane 2019
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  20. 20
    Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

    Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death od Joanne M. Hildebrand, Maria C. Tanzer, Isabelle S. Lucet, Samuel N. Young, Sukhdeep K. Spall, Pooja Sharma, Catia L. Pierotti, Jean‐Marc Garnier, Renwick C. J. Dobson, Andrew I. Webb, Anne Tripaydonis, Jeffrey J. Babon, Mark D. Mulcair, M.J. Scanlon, Warren S. Alexander, Andrew F. Wilks, Peter E. Czabotar, Guillaume Lessène, James M. Murphy, John Silke

    Wydane 2014
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